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 Other names for this medication :  Abaglin, Algia, Alidial, Alpentin, Apo-gab, Bapex, Blugat, Bosrontin, Brilian, Dineurin, Edion, Epiven, Epleptin, Equipax, Gabadoz, Gabagamma, Gabahasan, Gabahexal, Gabalept, Gabalich, Gabamerck, Gabanet, Gabaneural, Gabantin, Gabapen, Gabapentina, Gabapentine, Gabapentinum, Gabapin, Gabaran, Gabaront, Gabastad, Gabatal, Gabatem, Gabateva, Gabatin, Gabatine, Gabator, Gabatur, Gabax, Gabental, Gabentin, Gabex, Gabexal, Gabexine, Gabictal, Gabin, Gabiton, Gaboton, Gabrion, Gabtin, Gabture, Galepsi, Ganin, Gantin, Gapentek, Gapentin, Gapridol, Garbapia, Gatilox, Gordius, Kaptin, Katena, Logistic, Medivapom, Mirgy, Mycovit-gb,  Nepatic,  Neugabin,  Neurexal,  Neuril,  Neurogabin,  Neuropen,  Neuros, Neurostil, Neurotin, Nopatic, Normatol, Nupentin, Nurabax, Pendine,  Progresse,  Rangabax,  Ritmenal,  Semerial,  Symleptic,  Tebantin,  Ultraneutral, Yalipent, Zincobal-g.

Active Ingredient: Gabapentin
▻ Neurontin is used for treating seizures associated with epilepsy.

Each tablet contains 600 mg or 800 mg of gabapentin, as well as auxiliary substances: corn starch, talc, magnesium stearate, copovidone, hypolase, poloxamer 407, polishing wax, white “Opadray”.

Capsules contain 100, 300 or 400 mg of gabapentin and excipients: corn starch, lactose, talc.

Form of issue
The drug Neurontin is available in the following forms:

➢ Capsules of 100 mg, 300 mg and 400 mg; outside the capsule, white (100 mg), light yellow (300 mg) or gray-orange (400 mg), with a blue or gray inscription (name of the drug, amount of active substance and “PD”), inside a white or almost white powdery substance;

➢ Tablets coated with a white coating, 600 mg and 800 mg, elliptical, with the inscription black (600 mg) or orange (800 mg) color.

Pharmachologic effect
Medication Neurontin refers to anticonvulsants, antiepileptic drugs.

Pharmacodynamics and pharmacokinetics
Gabapentin, the active substance of Neurontin, is able to prevent convulsions.

Gabapentin is similar in structure to GABA, but does not affect its metabolism. Once in the body, it combines with the alpha-2-beta subunits of voltage-dependent calcium channels, which leads to a decrease in the flow of calcium ions and a decrease in the likelihood of developing neuropathic pain.

Also, gabapentin reduces the level of glutamate-dependent death of nerve cells, increases the formation of GABA, reduces the release of neurotransmitters of the monoamine group.

The maximum level of bioavailability is 60%, but it decreases with increasing dose. The maximum concentration in the blood plasma is achieved 2-3 hours after taking the medication. Gabapentin almost does not bind to plasma proteins (no more than 3%).

The half-life is approximately 5-7 hours, regardless of the dose taken. It is excreted from the body in an unmodified form solely due to the work of the kidneys.

Indications for use
The use of Neurontin is indicated in such cases:

⓵ Neuropathic pain (medication can be prescribed only to persons who have reached the age of 18);
⓶ partial seizures, regardless of the presence of secondary generalization (can be taken from 3 years as an addition to the main treatment, with 12 – as a monotherapy).

It is forbidden to prescribe Neuronthin:

➣ children under 3 years;
➣ with hypersensitivity to gabapentin.
Care must be taken when treating elderly patients or with kidney failure.

Side effects
Treatment with Neurontin can cause side effects on the part of most organs and body systems:

➲ digestive system: stool disorders, flatulence, nausea and vomiting, dry mouth, abdominal pain, dental disease, a sharp decrease or increase in appetite;
➲ general condition: weakness, headaches, flu-like syndrome, pain in various parts of the body, edema on the peripheral parts of the limbs and face, weight gain, fever, reduced resistance to viral infections;
➲ nervous system: memory, speech, thinking, gait, sensitivity, confusion, drowsiness, dizziness, tremor, depression, sudden mood swings, insomnia, hostility;
➲ respiratory system: dyspnea, hypersensitivity to infectious diseases of the respiratory system;
➲ skin: a rash, itching;
➲ cardiovascular system: vasodilation, increased blood pressure;
➲ hematopoiesis system: leukopenia, bruising, purpura;
➲ musculoskeletal system: pains in the joints, spine, muscles, propensity to fractures.

Neurontin, instructions for use (Method and dosage)
The medicine is taken orally during a meal or at any other time.

Scheme of treatment of neuropathic pain in adults:

⊳ the first day – 1 reception of 300 mg of a medicine;
⊳ the second day – 2 receptions of 300 mg;
⊳ the third day – 3 doses of 300 mg; in some cases, this dosage is prescribed ⊳ from the very beginning;
The next days – the dose depends on the effect and condition of the body – it is either left unchanged or gradually increased (the maximum dose is 3.6 g per day).
Dosage in the treatment of partial seizures in patients aged 12 years is selected according to a scheme similar to that described above. In order to prevent the resumption of seizures, care must be taken to ensure that the interval between doses of the drug does not exceed 12 hours.

Features of treatment of partial seizures in children 3-12 years:

⊳ the required dose is calculated according to the weight of the child;
⊳ from the first day a three-time appointment is appointed, with intervals of no more than 12 hours;
⊳ the initial dose is 10-15 mg / kg per day;
⊳ within three days, the dose from the initial is increased to effective;
⊳ effective dose: in 3-5 years – 40 mg / kg during the day; in 5-12 years – 25-35 mg / kg / day.
If there is a kidney failure, the dosage can be reduced. When correcting, it is necessary to focus on the creatinine clearance.

The appearance of such symptoms may indicate overdose:

▶ dizziness;
▶ unclear or confused speech;
▶ double vision in the eyes;
▶ drowsiness, even before the development of lethargic sleep;
▶ diarrhea.
In case of an overdose, measures should be taken to remove symptoms. If a person does not work well enough kidneys, especially in severe forms of kidney failure, hemodialysis is indicated.

The joint administration of Neurontin with other medications does not cause clinically significant reactions on the part of the body or changes in the mechanism of action of the drugs.

If a person takes antacids that contain aluminum and magnesium, it is desirable to maintain a gap of at least 2 hours between taking this drug and Neurontin. Alternatively, the bioavailability of gabapentin may decrease by approximately 20%.

With simultaneous application with Morphine, the pain threshold may be increased, but this phenomenon is not of great clinical significance. Very rarely with this combination, if the doses of Morphine and Neurontin are high, drowsiness appears. In this case, you need to reduce the dosage of one of the drugs.

Storage conditions
Keep in a cool, inaccessible place for children.

Shelf life
Shelf life of tablets – 2 years, capsules – 3 years.

Special instructions
When treating elderly people and patients with renal insufficiency, it is desirable to reduce dosage. If the patient undergoes hemodialysis, it should be noted that in this procedure gabapentin is well excreted from the plasma, so there may be a need for dose adjustment.

It is undesirable to drive vehicles or work with mechanisms that move during therapy with Neurontin.

To cancel a medicine or reduce a dose it is necessary gradually. A sharp decrease in the dose in most cases causes insomnia, sweating, anxiety, a feeling of nausea, pain in different parts of the body, sometimes convulsions.

In pregnancy and lactation
Data on the safety and efficacy of the drug during pregnancy or during breastfeeding is not enough to arrive at a final conclusion. Therefore, he is appointed only when there is a very high risk for a woman’s health.

In breast milk of women who are being treated with Neurontin, gabapentin is found. As it affects the child, it is unknown, therefore, feeding should be stopped.

Information about medicines on the site is a reference-generalizing, collected from public sources and can not serve as a basis for making a decision about the use of medications in the course of treatment. Before using the drug Neurontin necessarily consult with your doctor.⚠

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