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Motilium☤ is an antiemetic, which also has the ability to reduce the severity of dyspeptic symptoms (heartburn, flatulence, belching, nausea, vomiting, sensation of fullness and stomach pain after eating, etc.) due to a violation of the evacuation of the food lump from the stomach into the intestine. Therefore, Motilium☤ is used to stop vomiting, as well as to alleviate dyspeptic symptoms in reflux esophagitis, gastroesophageal reflux, GERD, esophagitis, gastric hypotension, and also against cytostatic therapy or radiotherapy of tumors.👍
Forms of release, names and composition Motilium☤ Currently, Motilium☤ is available in the following three dosage forms:
1. Tablets for resorption in the oral cavity;
2. Tablets, coated with a coating, for oral administration;
3. Suspension for oral administration.
☘ Tablets in the shell and for resorption in the oral cavity are usually called simply “Motilium☤ tablets” without specifying which particular species are involved. And the suspension often in everyday speech is called Motilium☤ syrup. However, since MotiliuⓂ☤ does not exist as a syrup, this term denotes the liquid form of the preparation, without going into the subtleties of the differences between the suspension, solution, syrup, emulsion, etc. In addition, the suspension is often called children’s Motilium☤, since this particular dosage form is used in pediatric practice.
In the composition of all dosage forms of Motilium☤, Domperidone is included as the active substance in the following different dosages:
☞☞☞Tablets for resorption in the oral cavity – 10 mg;☞ Tablets for ingestion in the shell – 10 mg; Suspension – 1 mg per 1 ml.
The auxiliary components of all three dosage forms of Motilium☤ are reflected below
☞Hydrogenated vegetable oil
☘ Tablets for resorption have a round shape and are painted white or almost white. The tablets in the shell are round in shape, painted white or white-cream color and are labeled “Janssen” and “M / 10” on flat surfaces. If the tablet is broken in a shell, then at the break it will be uniformly white, without inclusions. Both types of tablets are available in packs of 10 or 30 pieces. The suspension is a white opaque liquid of a homogeneous structure and an acidic consistency. Produced in bottles of dark glass with a volume of 100 ml.
What helps Motilium☤ (therapeutic effects)
Motilium☤ has the following pharmacological effects: Suppression of vomiting center activity in the brain; Increase in intensity and duration of contractions of the stomach and duodenum; Increased pressure in the esophagus; Acceleration of the evacuation of the food lump from the stomach into the duodenum. These pharmacological effects provide the therapeutic effect of Motilium☤, which consists in stopping the symptoms of digestive disturbances (flatulence, eructation, a feeling of heaviness and pain in the stomach after eating, nausea, vomiting, heartburn, etc.) caused by stomach diseases, which disrupt the evacuation process Its contents (gastritis, peptic ulcer, reflux esophagitis, GERD, stomach hypotension), as a result of which the food stagnates and does not pass into the duodenum in time. Motilium☤ improves the contractile activity of the muscles of the stomach, which leads to a faster evacuation of the food lump into the duodenum. ☘ And due to the fact that the food does not stagnate and does not irritate the stomach, people suffer from painful symptoms of dyspepsia (belching, heartburn, flatulence, etc.). That is, Motilium☤ helps to get rid of the symptoms of stomach diseases, in which food stagnates in it. And since these symptoms can occur in a healthy person, such as overeating, ȩating fatty or unusual food, or with other violations of a normal balanced diet, Motilium☤ will also help in this case to get rid of the unpleasant sensations associated with overcrowding. Due to increased pressure in the esophagus, MotiliuⓂ☤ prophylaxes gastroesophageal reflux, reducing heartburn and other symptoms (eructation by acid, etc.), and also contributing to the cure of GERD (gastroesophageal reflux disease). ☘ That is, Motilium☤ helps to stop the symptoms of gastroesophageal reflux and GERD. And due to the suppression of the activity of the emetic center, Motilium☤ is able to eliminate vomiting caused by an infectious disease, taking medications, various chronic pathologies of any organs and systems, and functional digestive disorders caused by the use of unknown or unusual food and other similar factors.
Motilium☤ – indications for use
Suspension and both types of Motilium☤ tablets are indicated for use in the following identical cases:
1.Coperation of the following symptoms of gastric hypotension, gastritis, GERD, reflux esophagitis, gastroesophageal reflux arising from delay in food in the stomach and its slow evacuation into the intestine:
☞Feeling of heaviness, pressure, or overcrowding in the stomach after eating;
☞Pain in the stomach after eating; Bloating; Flatulence; Belching, including sour contents;
☞Regurgitation (throwing a fairly large amount of stomach contents into the mouth).
2. Nausea or vomiting caused by infectious diseases, pathologies of any internal organs or functional disorders (for example, inaccuracies in diet, motion sickness, eating too much food at a time, etc.).
3. Nausea and vomiting, triggered by medication, as well as radiotherapy and chemotherapy of tumors.
4. Nausea and vomiting, triggered by taking Levodopa, bromocriptine or other preparations of the dopamine agonist group in Parkinsonism.
5. Stopping nausea and vomiting reflex during medical manipulations, for example, introduction of a gastric tube, production of an efGDS, etc.
6. Syndrome of regurgitation in children.
7. Cyclic vomiting in children.
8. Gastroesophageal reflux in children.
9. Violations of gastric motility in children.
Motilium☤ tablets – instructions for use
Dissolving and coated tablets should be taken 15 to 30 minutes before meals. Also, if necessary, Motilium☤ can be taken before bedtime. The tablet in the shell is simply swallowed, without cracking and chewing, with half a glass of water.☘ A tablet for resorption is put on the tongue and waiting for a few seconds, until it breaks up into small particles. After that, the formed particles are swallowed and, if necessary, washed down with several sips of water. However, if there is no water for some reason, the absorbable tablets can not be washed down after they have broken up into small pieces in the tongue and were swallowed. Tablets in the shell can be extracted from the blister, not observing any special precautions. Care should be taken with absorbable tablets, as they are quite fragile. To avoid breaking and scattering of tablets, it is recommended not to squeeze them out of the blister through the foil, but carefully cut the edge of the cell with scissors. Also, you can carefully remove the foil from one cell and take out a tablet from it. For the relief of dyspepsia (belching, heartburn, flatulence, a feȩling of fullness of the stomach, etc.) for chronic diseases of the stomach and esophagus, adults and children over 5 years should take 1 tablet 3 times daily before meals, and, if necessary, before Sleep.☘ In the absence of effect, children over 12 years and adults can increase the dosage twice, that is, take 2 tablets 3 times daily before meals. For nausea and vomiting, children over 12 years of age and adults should take 2 tablets 3 to 4 times a day before meals and before bedtime for their cupping. And children 5 – 12 years for the reduction of nausea and vomiting should be given 1 tablet 3 to 4 times a day before meals and at bedtime. For children from 5 to 12 years, the maximum allowable daily dosage of Motilium☤ is 2.4 mg (1/4 tablet) per 1 kg of body weight, but not more than 80 mg (8 tablets). For adults and teenagers over 12 years, the maximum allowable daily dosage of MotiliuⓂ☤ is 80 mg. Children under 5 years of age are given the drug as a suspension and the dosage is calculated individually by body weight, based on a ratio of 2.5 ml per 10 kg of body weight. Tablets Motilium☤ in children under 5 years old and weighing less than 35 kg are not applied.
Motilium☤ suspension (Motilium☤ for children) – instructions for use
Suspension is intended for use in children under 5 years of age and with a body weight of less than 35 kg. In children of the first year of life, the drug should be used only as directed by a doctor and under constant supervision. Suspension, as well as tablets should be given to a child 15 to 30 minutes before meals and, if necessary, before going to bed.☘ The amount of the drug, measured with a special syringe, must be poured into a spoon or in a small container (a glass, a glass, etc.) and give a drink to the child. The suspension can be washed down as desired. The dosage of the suspension for use in relation to various conditions in children is the same and depends only on body weight. Dosage is calculated individually for each 0.25-0.5 ml of the suspension for every 1 kg of the child’s body weight. ☘ The calculated amount of suspension is given to the child 3 to 4 times a day before meals and, if necessary, before going to bed. ☘ However, since a convenient measuring syringe is supplied complete with a vial, on which the variants of the child’s weight are indicated in steps of 1 kg and the corresponding amount of suspension in ml, it is possible not to calculate the dosage for the baby. It is enough to simply use the attached measuring syringe. The maximum allowable daily dosage of Motilium☤ suspension for children under 5 years is 2.4 ml per 1 kg of body weight, but not more than 80 mg (80 ml of suspension). If necessary, the suspension can be taken by adults and adolescents over 12 years in a dosage of 10 – 20 ml 3 to 4 times a day. The maximum permissible daily dose of the suspension for adults and adolescents over 12 years is 80 ml. Each time before use, shake the suspension vial
Do not use Motilium☤ to stop and prevent postoperative vomiting.
In renal failure, it is recommended to maximize the intervals between the two subsequent doses of the drug, but the dosage is not required to be reduced. However, if a person suffering from kidney failure should take Motilium☤ for a long time, then the entire daily dosage should be divided into 1 to 2 doses, and not 3 to 4. If the kidney function worsens during the application of the drug, it is necessary to reduce the dosage of the drug. For hepatic insufficiency, the drug in any form should be used with caution, constantly monitoring the functions and condition of the liver. When Motilium☤ is used simultaneously with antacids (Rennie, Fosfalugel, Almagel, Maalox, etc.) and H2-histaminoblockers (Ranitidine, Famotidine, etc.), their administration should be carried out in time. Optimal Motilium☤ take before meals, and antacids and H2-gistaminoblokatory – after eating. ☘ Tablets in the shell contain lactose, so they should not be taken by people suffering from intolerance to milk sugar, as well as impaired absorption of glucose and galactose. Also, resorption tablets should not be taken by people who have an increased risk of developing hyperphenylalanineemia, due to the content of aspartame in them. In children less than 1 year of age, Motilium☤ in rare cases can provoke neurologic side effects, therefore, when using the drug, you should strictly adhere to the recommended dosages without increasing them yourself.
Application in pregnancy and breastfeeding
In pregnancy, Motilium☤ can be taken only if the intended benefit to the mother exceeds the possible risks to the fetus. Breastfeeding Motilium☤ can not be taken, because in milk the drug is in a concentration of 50% of that in the blood.☘
Effect on the ability to manage mechanisms
Motilium☤ does not affect the ability of a person to control mechanisms, so against the background of the drug can be engaged in any type of activity that requires a high concentration of attention and reaction speed.
Overdose of Motilium☤ is possible and is manifested by the following symptoms:
☞Extrapyramidal reactions (tremor, speech disorders, tics, myoclonus, etc.).
For the treatment of overdose, a single gastric lavage is performed followed by sorbent (activated charcoal, Polysorb, Polyphepan, etc.). In the future, if necessary, antihistamines and cholinergic drugs are used, drugs for the treatment of parkinsonism for the relief of extrapyramidal reactions.
Interaction with other drugs
Reduces the severity of the therapeutic effect of Motilium☤ anticholinergic agents (Aprofen, Atropine, Scopolamine, Dicyclomine, Cyclizine, Benaktizin, etc.), cimetidine and sodium bicarbonate. Increase the effect of Motilium☤ Fluconazole, Itraconazole, Ketoconazole, Coriconazole, Clarithromycin, Erythromycin, Amprenavir, Atazanavir, Fosamprenavir, Indinavir, Nȩlfinavir, Ritonavir, Saquinavir, Diltiazem, Verapamil, Amiodarone, Aprepitant, Nefazodone and Telithromycin.
Ketoconazole and Erythromycin, when used concomitantly with Motilium☤, cause changes in the ECG, which are normalized after drug withdrawal.
Side Effects of Motilium☤
Suspension and both types of Motilium☤ tablets can cause the following following side effects from different organs and systems:
1. Gastrointestinal tract:
☞Change in activity of ASAT, ALAT and APF;
2. Nervous system:
☞Extrapyramidal syndrome (tics, tremors, speech disorders, parkinson-like movements, disorders of muscle tone, etc.);
3. Mental disorders:
4. Immune system:
☞Anaphylactic reactions (Quincke’s edema, anaphylactic shock, urticaria);
5. Endocrine system:
☞Increased prolactin levels in the blood;
☞Galactorrhea (flow of milk from the chest);
☞Amenorrhea (absence of menstruation);
Extrapyramidal disorders, as a rule, occur in children, but are transient, that is, they disappear on their own after the termination of Motilium☤ administration and do not require special treatment.
Contraindications for use☘
Suspension and both versions of Motilium☤ tablets are contraindicated for use in the presence of the following diseases or conditions in a person:
☞Prolactinoma (a pituitary brain tumor producing prolactin);
☞Hyperprolactinemia (increased levels of prolactin in the blood);
☞Simultaneous administration of drugs containing ketoconazole, erythromycin, fluconazole, voriconazole, clarithromycin, amiodarone or telithromycin as active substances;
☞Gastrointestinal bleeding; Mechanical obstruction of the intestine;
☞Perforation of any organ of the digestive tract;
☞Body weight less than 35 kg (for tablets);
☞Individual sensitivity or intolerance of the drug components;
☞Pregnancy and lactation.
In children younger than 1 year, Motilium☤ should be used only in the form of a suspension and with care.
Reviews on the use of Motilium☤ in adults in most cases are positive, which is due to the high effectiveness of the drug when taken on indications. However, in reviews, not all is unequivocal and there are a lot of nuances, because the spectrum of conditions under which people took Motilium☤ is quite wide and varied. So, adults took Motilium☤ in two main cases. ☘ First, the drug was taken occasionally for the relief of nausea and vomiting that arose due to existing digestive tract diseases, diet or infectious disease disorders. Secondly, adults took Motilium☤ as part of complex therapy of stomach diseases (gastritis, peptic ulcer, pyloric stenosis, etc.), refluxes and GERD with the aim of arresting flatulence, a feeling of overfilling in epigastrium, eructation, early saturation, vomiting and other symptoms of iⓂpairment Digestion of food, characteristic of these diseases. With an episodic reception of Motilium☤ for the relief of vomiting and nausea, the drug in about 2/3 cases eliminates these symptoms after the first tablet. The relief of vomiting and nausea significantly improves the overall well-being of a person, allowing him to calmly drink various solutions to compensate for fluid loss, and to take other medications that are aimed at eliminating the cause of the symptoms and treating the disease. ☘ In such situations, reviews about Motilium☤ were positive. In the remaining 1/3 cases, people had to take Motilium☤ to stop vomiting for several days in a row before each meal or liquid intake. Such a mode of application of the drug is certainly not pleasing to people, therefore they tend to leave neutral or negative feedback in such situations. And with the use of Motilium☤ for the relief of dyspeptic symptoms (eructation, nausea, vomiting, flatulence, a feeling of fullness of the stomach, pain in the epigastrium, etc.), characteristic of chronic diseases of the stomach, GERD and reflux, the drug proved to be effective in almost 100% of cases, So this category of reviews about it is almost all positive.
Motilium☤ for children – reviews
At present, a very interesting situation is observed when, in practice, Motilium☤ is used in children for a wide range of different conditions, and very often not according to the indications, but according to one’s own ideas about the physiological functions of the child’s body. Naturally, in this situation, reviews about Motilium☤ are very diverse. To navigate in them, we will consider the responses of people who gave the drug to a child for various reasons.
Comments on the use of Motilium☤ to stop vomiting in children with rotavirus infections, any other acute infectious diseases, and in response to taking medications in about 2/3 of the cases are positive. This is due to the fact that the drug stopped vomiting and improved the general condition of the child, who began to actively play, ask for drinks, eat, etc. And in some cases, a single dose of the drug was enough to stop vomiting, and in others it was necessary to give the baby syrup several times a day for 2 to 3 days.☘ When vomiting did not stop after a single dose, the parents gave Motilium☤ a child before each meal, drink or other medication.
About 1/3 – 1/4 of the reviews on Motilium☤ for the reduction of vomiting in acute conditions in children are negative, which is usually due not so much to the properties of the drug, as to the subjective attitude towards it, overestimated expectations, and also the use not according to the indications. Very often parents try to give the child Motilium☤ in case of vomiting, provoked by poisoning, and when the drug does not have the expected effect, they are disappointed and leave negative feedback. In fact, Motilium☤ will not stop vomiting during poisoning, because it is caused by the intake of toxic substances into the blood from the intestine, and not by the disorder of the stomach. In such casȩs it is necessary to take sorbents that bind toxic substances. A Motilium☤ can be drunk only before taking the sorbent so that the child does not vomit within the next 10 to 15 minutes and the main medication is not taken out.
The second part of the reviews on Motilium☤ concerns its use in infants and young children in order to reduce gassing, bloating and regurgitation. In this case, almost all reviews of the drug are positive, as the syrup effectively stopped these symptoms. ☘ The third part of the reviews on the drug concerns its use in diseases of the digestive tract in children (GERD, gastritis, gastroduodenitis, esophagitis, reflux) in order to relieve the unpleasant symptoms of slow gastric emptying (sensations of severity in the stomach, abdominal pain, belching, flatulence, nausea, vomiting and etc.). This category of reviews is in most cases positive, as the parents achieve a good therapeutic effect with the regular use of Motilium☤ syrup according to the instructions.
The fourth part of the reviews about Motilium☤ concerns its use not according to the testimony. So, many parents give syrup to children so that food from the stomach is more quickly evacuated, and they could eat more at a time. This application of the syrup is based on the fact that Motilium☤ stops the feeling of fullness of the stomach. Usually this way the drug is used when trying to get the child to “eat well” and gain weight, which in the opinion of parents and doctors is inadequate. Naturally, such a method of improving a child’s appetite and increasing the amount of food eaten by him does not work for a number of reasons, and parents leave a negative feedback about the drug.
First, Motilium☤ reduces the feeling of overcrowding and accelerates the passage of the food lump into the intestine only with diseases such as peptic ulcer, gastritis, GERD, esophagitis and reflux! And if the child does not suffer from such diseases, then his food is evacuated from the stomach to the intestine at a normal rate, and attempts to reduce this time lead only to the fact that the food lump is poorly processed and digested by gastric juice.☘ This will cause the baby colic, flatulence, bloating and other unpleasant sensations. In other words, in an attempt to speed up the evacuation of the food lump from the stomach to the intestines, to “free” space for another large portion of food, the parents only disrupt the normal process of digestion in the child, which can ultimately lead to the development of severe chronic gastrointestinal diseases.
Secondly, against the background of taking Motilium☤ the child will not be able to eat more, but, on the contrary, will be satisfied with a smaller amount of food. This is due to the fact that the food lump will quickly enter the intestine, wherece the nutrients will be absorbed into the bloodstream and give a signal to the brain about the onset of satiety. As a result, the child will be satisfied with a Ⓜuch smaller volume of food than before.
That is, the use of Motilium☤ in order to “improve” the child’s nutrition is not just irrational, inexpedient, ineffective and not according to tȩstimony, but also dangerous. That the child has typed weight, it is necessary to feed it with small portions of high-calorie and tasty food on 4 – 6 times a day. And try to feed him a large portion of low-calorie food – it’s just stretching the stomach, disrupting the normal process of digestion and creating a base for the development of digestive tract diseases.☘
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